Kidney marker - Creatinine

What does creatinine mean on your blood test?

Creatinine is a waste product your kidneys filter out of your blood, so its level is a common way to check how well your kidneys are working. Here is how to read yours.

Reported as
Serum creatinine
mg/dL
Paired with
eGFR (estimated filtration)
mL/min/1.73m²

What creatinine is

Creatinine is a waste product made by your muscles during normal activity. Healthy kidneys filter it out of your blood and remove it in urine, so the amount left in your blood reflects how well your kidneys are filtering. It is measured in mg/dL, usually as part of a metabolic panel.

How to read your creatinine

Creatinine levels are affected by muscle mass, age, and sex, so the normal range varies from person to person and lab to lab. A higher creatinine can suggest the kidneys are filtering less effectively. It is often reported alongside eGFR, an estimate of kidney filtration calculated from your creatinine. Your clinician reads them together.

What a high level can mean

A higher creatinine can point toward reduced kidney function, but it can also be influenced by dehydration, certain medicines, and having more muscle. A single result is a starting point. Your clinician may repeat the test, look at eGFR, and consider your history before drawing conclusions.

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Common questions

What does high creatinine mean?
A higher creatinine can indicate that the kidneys are filtering less effectively, but it can also rise with dehydration, some medicines, and greater muscle mass. Your clinician interprets it alongside eGFR and your history rather than from the number alone.
How does creatinine relate to eGFR?
eGFR is an estimate of how well your kidneys filter, calculated largely from your creatinine along with factors like age and sex. They are reported together because eGFR puts the creatinine number into context.
Can creatinine change from day to day?
Yes, factors such as hydration, recent intense exercise, and diet can influence it. That is one reason a single elevated result is often rechecked before any conclusion is reached.

Sources

  1. MedlinePlus [Internet]. Bethesda (MD): National Library of Medicine (US); Creatinine Test; [cited 2026 Jul 9]. Available from: https://medlineplus.gov/lab-tests/creatinine-test/
  2. MedlinePlus [Internet]. Bethesda (MD): National Library of Medicine (US); Creatinine; [cited 2026 Jul 9]. Available from: https://medlineplus.gov/creatinine.html
  3. MedlinePlus [Internet]. Bethesda (MD): National Library of Medicine (US); Kidney Tests; [cited 2026 Jul 9]. Available from: https://medlineplus.gov/kidneytests.html

Content last reviewed 9 July 2026. Reference ranges vary by laboratory; always read your results against the range printed on your own report.

This page explains a common lab marker in general terms using public information from the U.S. National Library of Medicine and other NIH sources. It is educational and is not a diagnosis or medical advice. Reference ranges differ between laboratories and the meaning of a result depends on your age, sex, medications, and overall health. Always discuss your own results with the clinician who ordered them.